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13th International Conference on Malignant Lymphoma

 

17-20 June 2015 Lugano
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Discussion forum - 13th International Conference on Malignant Lymphoma
    Topic - Aggressive B-cell lymphoma

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Poster: 163
Visits: 49
Title: Molecular characterization of diffuse large B-cell lymphoma recurrences: clonal relationship and different modes of tumor evolution
Authors: Darius Juskevicius , J. Gsponer, A. Rufle, C. Ruiz, S. Dirnhofer, A. Tzankov
Centre: Institute of Pathology Basel

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MOLECULAR CHARACTERIZATION OF DIFFUSE LARGE B-CELL LYMPHOMA RECURRENCES: CLONAL RELATIONSHIP AND DIFFERENT MODES OF TUMOR EVOLUTION

Darius Juskevicius
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Subspeciality
Reg: 6/8/2015 8:19:00 PM
Comment# 1
Recurrences of diffuse large B-cell lymphomas (DLBCL) represent a source of significant morbidity and mortality, but their underlying genetic and biological mechanisms remain to be elucidated. We used immunoglobulin rearrangement analysis, copy number aberration profiling and next generation sequencing to investigate clonal relationship and genetic evolution in 20 matched primary-relapse DLBCL sample pairs. We compared this genomic data to the analogous data from 11 non-relapsing DLBCL cases attempting to identify relapse-specific genetic events. We have concluded firstly, that distinct genetic evolution patterns of diffuse large B-cell lymphoma relapse exist and include clonally unrelated de novo recurrences. These patterns can be reconstructed by interpreting DNA mutation and copy number aberration data. Secondly, genomes of relapsing and non-relapsing diffuse large B-cell lymphomas differ significantly in recurrent copy number aberrations.

Comment added on 6/8/2015 8:19:00 PM 
     
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Most viewed poster for this congress
Poster: 9
Visits: 649
Title: Ibrutinib in combination with Rituximab for Relapsed Mantle Cell Lymphoma: An Update from a Phase II Clinical Trial
Authors: Michael Wang ,
Centre: The University of Texas MD Anderson Cancer Center

Poster most viewed in this topic
Poster: 154
Visits: 188
Title: NR4A3 suppresses lymphomagenesis by induction of apoptosis and serves as a drug target for lymphoma therapy
Authors: Alexander Deutsch ,
Centre: Clinical Devision of Hematology


 




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